Why human body is vulnerable to Epidermodysplasia Verruciformis disorder is it

Epidermodysplasia verruciformis (EV) is a rare, autosomal recessive inherited skin disorder characterised by eruptions of wart-like lesions that may occur anywhere on the body. These lesions are caused by infection with the human papillomavirus (HPV).

Epidermodysplasia verruciformis (EV) is a rare, inherited disorder that predisposes patients to widespread human papillomavirus (HPV) infection and cutaneous squamous cell carcinomas. [1, 2, 3, 4] Although epidermodysplasia verruciformis is most commonly inherited in an autosomal recessive manner, [5] sporadic, sex-linked, and autosomal dominant inheritance have been described. In those cases of autosomal recessive inherence, there may be a history of consanguinity in the parents of the afflicted individual. In those cases of atypical inheritance, there may be an association with chronic lymphopenias. Regardless of the mode of inheritance, the phenotype of the disease is characterized by chronic infection with HPV. Widespread skin eruptions of flat-to-papillomatous, wartlike lesions and reddish-brown pigmented plaques on the trunk, the hands, the upper and lower extremities, and the face are typical.